The 6th Annual Conference [Report]
The 6th Annual Meeting, held on Sunday, September 18, 2022, was held simultaneously at the venue and online, and was attended by many people, including medical professionals, general business people, people from research institutions, patients, and the general public.
We would like to take this opportunity to thank everyone for making the event a success despite the coronary disaster. We also thank you for your cooperation in preventing the spread of infection at the venue.
opening
opening address
►Dr. Zen Tanaka, Representative Director (President, Tanaka Clinic, Jinzenkai Medical Corporation )
Dr. Zen Tanaka, President and Representative Director of the Society, gave the opening remarks.
He expressed his gratitude for the successful 6th anniversary of the Society’s establishment in 2017, and asked for cooperation in future efforts to address various diseases in addition to ASD.
Renal Disease Initiatives
The morning session started with Dr. Zen Tanaka’s approach to renal disease. The chairperson was Dr. Masayuki Asaueholm, Director of LAGOM Life Clinic Tateshina.
►Dr. Zen Tanaka (President, Tanaka Clinic, Jinzenkai Medical Corporation )
DR. TANAKA IS PRACTICING MEDICINE WITH A MIND TO CONTRIBUTE TO THE DEVELOPMENT OF PREVENTIVE MEDICINE BY PROMOTING INTEGRATIVE MEDICINE THAT MAKES FULL USE OF MOLECULAR NUTRITION, IMMUNOLOGY, DENTISTRY AND ORAL HEALTH ENVIRONMENT, ETC., WITH A FOCUS ON ADVANCED CANCER TREATMENT. HE TALKED ABOUT THE CLINICAL VALIDATION OF FMT FOR RENAL DISEASE, WHICH HE IS GOING TO PROMOTE IN THE FUTURE, AND THE POSSIBILITY THAT FMT CAN SUPPRESS THE DECLINE OF RENAL FUNCTION.
Jinzenkai Tanaka Clinic President
OUR RESEARCH GROUP HAS BEEN SUCCESSFUL IN CLINICAL STUDIES OF INTESTINAL FLORA TRANSPLANTATION (FMT) NOT ONLY IN GASTROINTESTINAL DISEASES SUCH AS ULCERATIVE COLITIS AND IRRITABLE BOWEL SYNDROME, BUT ALSO IN AUTISM SPECTRUM DISORDER IN CHILDREN AND ALLERGIC DISEASES SUCH AS ATOPIC DERMATITIS. IN THE FUTURE, I WOULD LIKE TO ADVANCE CLINICAL VALIDATION FOR RENAL DISEASES. FROM THE VIEWPOINT OF GUT-RENAL RELATIONSHIP, FMT MAY BE ABLE TO SUPPRESS THE DECLINE OF RENAL FUNCTION IN CONSERVATIVE RENAL FAILURE BEFORE THE INTRODUCTION OF DIALYSIS, FOR WHICH THERE IS NO ACTIVE TREATMENT. IN THIS ISSUE, I WOULD LIKE TO RAISE THE ISSUE OF THE APPLICATION OF FMT FOR RENAL DISEASES.
►Dr. Shosei Toyofuku (Director, Hyogo Minato Veterinary Hospital )
Dr. Toyofuku is a veterinarian who is committed to providing medical care that not only keeps animals healthy, but also listens to the wishes of their families. He is currently testing hydrogen NanoGAS® water and intestinal flora transplantation in dogs and cats with renal disease, and reported on the progress of the trial.
Hyogo Minato Veterinary Hospital Director
FECAL MICROBIOTA TRANSPLANTATION (FMT) IN VETERINARY MEDICINE HAS BEEN REPORTED IN A WIDE RANGE OF ANIMAL SPECIES, INCLUDING DOGS, CATS, PIGS, HORSES, CATTLE, POULTRY, AND MONKEYS, SUGGESTING THAT IT MAY BE AN EFFECTIVE TREATMENT, ALTHOUGH IT IS NOT YET A TREATMENT WITH A HIGH LEVEL OF EVIDENCE. CHRONIC KIDNEY DISEASE (CKD) IS ROUTINELY ENCOUNTERED IN DOGS AND CATS, WITH A PARTICULARLY HIGH INCIDENCE IN OLDER CATS, AND IS COMMONLY TREATED WITH THERAPEUTIC DIETS, INFUSION THERAPY, AND DRUG THERAPY. WE HAVE HAD THE OPPORTUNITY TO PERFORM FMT IN DOGS AND CATS WITH CKD AND REPORT ON THE PROGRESS OF THIS STUDY.
Inflammatory bowel disease case report
The next chairperson was Dr. Yuichi Kawai, President of Kawai Internal Medicine Clinic, YUAKAI Medical Corporation.
►Dr. Mamoru Kimura (Chairman of the Board of Directors, Kimura Hospital, Medical Corporation Keimeikai )
The hospital was established in 1972 to provide health care and medical rehabilitation in the community, and has been working on various diseases beyond the department of medicine in the field of intestinal flora transplantation.
Medical Corporation Keimeikai Kimura Hospital President
Fecal microbiota transplantation (FMT) is a promising method to improve dysbiosis of the intestinal microflora. The Gut Flora Transplantation Clinical Research Group is performing FMT transplantation (NanoGAS®-FMT) using nanobubble water with dissolved microbubbles. In this report, we describe the usefulness, safety, and simplicity of the procedure in cases of ulcerative colitis and irritable bowel syndrome treated with NanoGAS®-FMT at our hospital, which provides primary care in the community.
NanoGAS® Water Basic Research Presentation
Risako Morishita ( Symbiosis Inc.)
We are pleased to report a new research project in 2022.
Symbiosis, Inc.
NanoGAS® (Nanobubble) has high potential as a multifunctional material for living organisms as well as the ability to hold gases in liquids for long periods of time. Nanobubbles in general are beginning to be utilized in cleaning and various industries, but their usefulness in the health sciences is still in its infancy. We are exploring the potential of NanoGAS® as a “new modality” in the pharmaceutical and medical fields by understanding its unique physicochemical properties that are endlessly fascinating and conducting basic research. This year, we also turned our attention to the food processing industry and clarified the usefulness of NanoGAS® for general use. In this issue, we would like to report a summary of our research results over the past two years.
Luncheon Seminar
► Ms. Ai Kitamura (Fermented Food Specialist / President of Love I Food Education, Inc.)
Based on her own experience as a sickly person who gained the strength to live through food, Ms. Kitamura proposes a delicious and happy diet through living fermented food. He taught us how to refrain from refined sugar.
Fermented Food Specialist / President, Love I Food Education, Inc.
One of the things we want to avoid when it comes to our intestines is refined sugar. Today, sweets can be purchased at convenience stores at any time. ‘I want to eat something sweet, but I want to avoid it, so what can I do?’ There are many people who have such problems. I used to love sweets, too, but it was amazake that allowed me to graduate from sweets. Amazake is rich in oligosaccharides and fermented metabolites, and is a great sugar for the intestines. You can use this amazake to make delicious sweets and even use it in cooking. We will show you the charm of fermented seasonings.
About Us
During the lunch break, we introduced our sponsors.
keynote speech
The afternoon session started with a keynote lecture on ASD. The chairperson was Dr. Masahiko Shirotani, Executive Director of Luke’s Ashiya Clinic.
Kenji Tsuchiya, Ph.D. (Specially Appointed Professor, Research Center for Child Mental Development, Hamamatsu University School of Medicine)
Professor Kenji Tsuchiya, who has been researching “children’s mental development” along with Professor Taiichi Katayama, who gave the keynote speech last year, joined us on stage.
THE “GAZE FINDER,” A VIEWPOINT MEASUREMENT DEVICE THAT IS ALSO USED IN OUR STUDY GROUP TO MEASURE ASD CHILDREN BEFORE AND AFTER THEIR IMPLANTATION, WAS DEVELOPED JOINTLY BY HAMAMATSU MEDICAL UNIVERSITY, OSAKA UNIVERSITY GRADUATE SCHOOL, KANAZAWA UNIVERSITY, CHIBA UNIVERSITY, UNIVERSITY OF FUKUI UNITED GRADUATE SCHOOL OF CHILD DEVELOPMENT, AND JVC KENWOOD WITH THE AIM OF OBJECTIVELY MEASURING SOCIAL SKILLS IN INFANTS. THE “SOCIALITY FINDER” WAS DEVELOPED JOINTLY BY HAMAMATSU MEDICAL UNIVERSITY, OSAKA UNIVERSITY GRADUATE SCHOOL, KANAZAWA UNIVERSITY, CHIBA UNIVERSITY, FUKUI UNIVERSITY UNITED GRADUATE SCHOOL OF CHILD DEVELOPMENT, AND JVC KENWOOD.
GazeFinder is a measurement device that enables visualization, objective and quantitative evaluation of a person’s interests and their relationship to brain function through the measurement of eye gaze by simply looking at a screen for about two minutes, and shows what people are interested in and what they are following with their eyes.
Dr. Tsuchiya has made significant contributions to the research and development of the Gaze Finder.
Specially Appointed Professor, Center for Research on Child Mental Development, Hamamatsu University School of Medicine
THE PREVALENCE OF AUTISM SPECTRUM DISORDER (ASD), A NEURODEVELOPMENTAL DISORDER, IN CHILDREN IS 2-3%. RECENTLY, SOCIAL UNDERSTANDING OF “DEVELOPMENTAL DISABILITIES” AND “AUTISM SPECTRUM DISORDERS” HAS EXPANDED, AND AWARENESS OF REASONABLE ACCOMMODATIONS HAS INCREASED. HOWEVER, THE CAUSES OF ASD REMAIN UNKNOWN, AND THERE ARE NO BIOLOGICAL TREATMENTS WITH ESTABLISHED EFFICACY. THEREFORE, IN ORDER TO WORK WITH INDIVIDUALS WITH ASD IN CLINICAL SETTINGS, WE MUST HAVE INSIGHT AND VISION ON HOW TO DEVELOP AND USE THE LIMITED KNOWLEDGE, KNOW-HOW, AND TECHNIQUES AVAILABLE TO US. THIS PRESENTATION WILL ATTEMPT TO SUMMARIZE RECENT SCIENTIFIC FINDINGS ON THE CLINICAL FEATURES OF ASD AND ITS BIOLOGICAL AND PHYSIOLOGICAL BACKGROUND. IT WILL ALSO INTRODUCE HOW ASD IS DIAGNOSED IN CLINICAL PRACTICE AND WHAT KIND OF THERAPEUTIC INTERVENTIONS ARE PROVIDED TO CHILDREN WITH ASD. THE DISCUSSION WILL THEN FOCUS ON HOW “SCIENTIFIC FINDINGS” AND “REALISTIC PRACTICE IN CLINICAL SETTINGS” SHOULD BE BLENDED, WITH A PARTICULAR EMPHASIS ON HOW ASD IS DIAGNOSED.
ASD CASE REPORT
Dr. Shirotani’s case report was chaired by Dr. Kunihiro Kitamura, Director of Kitamura Clinic, Kiwakai Medical Corporation, who is also a board member.
He also introduced Dr. Shirotani’s book.
► Dr. Masahiko Shirotani (Director, Luke’s Ashiya Clinic )
By using conventional medicine, molecular nutrition, and a psychological approach, he aims to find the root cause of symptoms and treat them to bring out the “self-healing power” that all people have, without relying on drugs alone.
CONTINUING FROM LAST YEAR, HE PRESENTED A SERIES OF CASES OF ASD AND THE CHANGES BEFORE AND AFTER TRANSPLANTATION BASED ON MULTIPLE INDICATORS SUCH AS INTESTINAL FLORA BALANCE, GAZE FINDER, AND SRS-2.
Luke’s Ashiya Clinic Director
THE CAUSES OF AUTISM SPECTRUM DISORDER (ASD) HAVE NOT YET BEEN IDENTIFIED, AND NO DRASTIC TREATMENT HAS YET BEEN ESTABLISHED. In recent years, it has become clear that dysbiosis is associated with symptoms of ASD, and the efficacy and safety of correcting the intestinal microbiota by means of intestinal flora transplantation (Fecal Microbiota Transplantation (FMT)) has been discussed. The efficacy and safety of correcting the intestinal microbiota through fecal microbiota transplantation (FMT) and other means are now being discussed. We have been performing FMT with NanoGAS®︎ water for ASD since the inception of our study group in 2017 and have experienced in some cases a reduction in symptoms such as tantrums and poor switching immediately after FMT as well as improved communication. In this report, we discuss the trend of intestinal microbiota, which we consider characteristic of ASD, and report a case of ASD in which FMT using NonaGAS®︎ was effective, along with literature review. 
panel discussion
“The Future of Children with Autism Spectrum Disorders.”
Dr. Kenji Tsuchiya (Specially Appointed Professor, Research Center for Child Mental Development, Hamamatsu University School of Medicine)
Dr. Taiichi Katayama (Vice Dean, United Graduate School of Child Development, Osaka University / Professor, Division of Molecular Biogenetics)
Dr. Masahiko Kidani (Director, Luke’s Ashiya Clinic )
Ms. Naomi Hatanaka (Representative, General Incorporated Association Challenged LIFE)
Dr. Kunihiro Kitamura (President, Kitamura Clinic, Kiwakai Medical Corporation )
Dr. Tsuchiya, Prof. Katayama, Dr. Kitamura, and Ms. Hatanaka, whose son had undergone a transplant, each offered their opinions from their respective standpoints, with Dr. Shirotani serving as facilitator.
IN ADDITION, WE ANSWERED QUESTIONS ABOUT ASD SUBMITTED BY PARTICIPANTS AT THE EVENT AND ONLINE.
Prospects for NanoGAS® Water Research
►Shin Shimizu, Senior Researcher, Symbiosis, Inc.
In the past year, the patents for “Intestinal Flora Transplantation Using Nanobubbles” and “Manufacturing Method and Device for Nanobubble Generator” have been granted, and the uniqueness of the intestinal flora transplantation of our research group has become clear.
This summer, we completed the first unit of the “automatic purification system for bacterial solution,” which we declared at last year’s annual conference that we would begin development. This has enabled purification in an environment more suitable for intestinal bacteria.
He spoke about the possibility of intestinal flora transplantation, which is evolving further.
Symbiosis, Inc.
The earliest known origin of intestinal flora transplantation is said to be around the 4th century in China, where the first case of treatment was when a healthy person’s stool was placed in the buttocks of a person who had diarrhea that would not stop, and the diarrhea was cured. Since then, research on fecal microbiota transplantation (intestinal flora transplantation) has progressed in Western countries, starting with a report on pseudomembranous enteritis in 1958. IN 2013, A STUDY IN THE NETHERLANDS TRIGGERED A THERAPEUTIC EFFECT AGAINST CLOSTRIDIOIDES DIFFICILE INFECTION (CDI), AND IN 2014, THE U.S. FOOD AND DRUG ADMINISTRATION (FDA) POSITIONED “INTESTINAL FLORA TRANSPLANTATION AS THE TREATMENT OF FIRST CHOICE WHEN CDI IS MULTIDRUG-RESISTANT,” AND ITS EFFECTIVENESS IS BEING MEDICALLY THE EFFECTIVENESS OF THIS THERAPY IS BEING MEDICALLY PROVEN. We have put into practical use a technology that allows the intestinal bacteria of others to settle in the recipient’s intestinal mucosal layer, without the use of antibiotics, using our proprietary and patented “NanoGAS®” technology for stool lysis. Our next goal is to purify the bacterial solution for transplantation in an environment as close to the intestinal tract as possible. I will talk about the development of the world’s first automated purification system for bacterial solution, “Monotone,” and our future goal, NanoGAS®-FMT.
Future Initiatives
“The Possibility of Intestinal Flora Transplantation.”
Dr. Kunihiro Kitamura (President, Kitamura Clinic, Medical Corporation Kiwakai )
Dr. Reiko Haruna (Vice President, Haruna Clinic, Medical Corporation )
Dr. Shoko Arisawa (Director, Hoshigaoka Dermatology, Medical Corporation Aiseikai )
Dr. Shinzo Waku (Director, Waku Clinic )
Dr. Yuichi Kawai (President, Cute Medicine Clinic, Medical Corporation Yuakai )
The doctors who are actually involved in transplantation and who have developed a skin lotion sold exclusively within the hospital using NanoGAS® spoke about the future possibilities of intestinal flora transplantation and research groups.
closing address
►Dr. Masahiko Shirotani, Executive Director (Director, Luke’s Ashiya Clinic)
Finally, Dr. Masahiko Shirotani, Executive Director, closed the meeting by thanking the participants for their continued support and announcing next year’s 7th Annual Conference.
About the 7th Annual Conference
The 7th Annual Meeting will be held as follows.
We look forward to seeing you at the conference, where we will present the results of our daily research, including basic research reports and case reports on intestinal flora transplantation.
Finally.
We would like to thank everyone for their support and cooperation in making this event a success despite the Corona disaster and typhoon. Thank you very much.
Next year, we hope to take another step forward from this year, and we will continue our daily research so that we can solve your problems as much as possible. Thank you for your continued support.
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