{"id":10327,"date":"2021-05-31T16:21:00","date_gmt":"2021-05-31T07:21:00","guid":{"rendered":"https:\/\/symdfmtcopro.wpenginepowered.com\/post\/10327"},"modified":"2023-11-15T19:05:29","modified_gmt":"2023-11-15T10:05:29","slug":"fmt-is-effective-against-parkinsons-disease-and-resistant-bacteria-2021-5-31","status":"publish","type":"post","link":"https:\/\/fmt-japan.org\/en\/post\/10327","title":{"rendered":"FMT IS EFFECTIVE AGAINST PARKINSON&#8217;S DISEASE AND RESISTANT BACTERIA [2021.5.31]."},"content":{"rendered":"\r\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"682\" class=\"wp-image-6733\" src=\"https:\/\/fmt-japan.org\/wp-content\/uploads\/2021\/05\/90f9256aa0ffa6c214daf0f4a3451a98-1024x682.png\" alt=\"\" srcset=\"https:\/\/fmt-japan.org\/wp-content\/uploads\/2021\/05\/90f9256aa0ffa6c214daf0f4a3451a98-1024x682.png 1024w, https:\/\/fmt-japan.org\/wp-content\/uploads\/2021\/05\/90f9256aa0ffa6c214daf0f4a3451a98-300x200.png 300w, https:\/\/fmt-japan.org\/wp-content\/uploads\/2021\/05\/90f9256aa0ffa6c214daf0f4a3451a98-768x511.png 768w, https:\/\/fmt-japan.org\/wp-content\/uploads\/2021\/05\/90f9256aa0ffa6c214daf0f4a3451a98.png 1280w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\r\n\r\n\r\n\r\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"i\"><\/span>FMT RELIEVES SYMPTOMS OF PARKINSON&#8217;S DISEASE<span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n\r\n\r\n\r\n<p>(Original)<br \/><a href=\"https:\/\/microbialcellfactories.biomedcentral.com\/articles\/10.1186\/s12934-021-01589-0\">Evaluation of fecal microbiota transplantation in Parkinson&#8217;s disease patients with constipation | Microbial Cell Factories | Full Text<\/a><\/p>\r\n\r\n<p>Patients with Parkinson&#8217;s disease suffer from conditions such as constipation and motor and non-motor symptoms. ( (<a href=\"https:\/\/www.neurology-jp.org\/Journal\/public_pdf\/049110888.pdf\" target=\"_blank\" rel=\"noopener\">Pathophysiology of Parkinson&#8217;s Disease: Motor and Non -Motor Symptoms<\/a>))<\/p>\r\n\r\n<p>A research team from Nanjing Medical University in China, Chun-li Zhou, and colleagues conducted a study in which 11 Parkinson&#8217;s disease patients with constipation symptoms underwent FMT.<\/p>\r\n\r\n\r\n\r\n<p>Results showed that motor and non-motor symptoms, typical symptoms of Parkinson&#8217;s disease, were reduced, and SIBO symptoms were also improved.<br \/>It also showed a change in the face of intestinal bacteria, with an increase in Blautia and Prevotella, but a significant decrease in Bacteroidetes.<\/p>\r\n\r\n\r\n\r\n<p>THIS STUDY NOT ONLY SHOWED A RELATIONSHIP BETWEEN GUT BACTERIA AND PARKINSON&#8217;S DISEASE, BUT ALSO INDICATED THAT FMT MAY SHED LIGHT ON THE TREATMENT OF PARKINSON&#8217;S DISEASE.<\/p>\r\n\r\n\r\n\r\n<p>(Reference article in English)<br \/><a href=\"https:\/\/parkinsonsnewstoday.com\/2021\/05\/18\/fecal-transplants-relieve-parkinsons-constipation-reduce-motor-non-motor-symptoms-small-study-finds\/\">Fecal Transplants Relieve Parkinson\u2019s Constipation, Motor Symptoms<\/a><\/p>\r\n\r\n\r\n\r\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"i-2\"><\/span>PARKINSON&#8217;S DISEASE AND GASTROINTESTINAL SYMPTOMS, POSSIBLE INTESTINAL BACTERIA AND FMT<span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n\r\n\r\n\r\n<p>\uff08original\uff09<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00415-021-10567-w\">Gastrointestinal dysfunction in Parkinson\u2019s disease: molecular pathology and implications of gut microbiome, probiotics, and fecal microbiota transplantation | SpringerLink<\/a><\/p>\r\n\r\n\r\n\r\n<p>Vinod Metta and his team at King&#8217;s College London, UK, are exploring gut bacteria-based methods, including FMT, as an approach to Parkinson&#8217;s disease.<\/p>\r\n\r\n\r\n\r\n<p>The presence of constipation and a biomarker called alpha-synuclein are used to diagnose Parkinson&#8217;s disease in its early stages.<\/p>\r\n\r\n\r\n\r\n<p>The research team hypothesized that a disturbed intestinal environment may cause oxidative stress and inflammation of the mucosa, which induces \u03b1-synuclein.<br \/>They then proposed a new aspect of the brain-gut correlation, in which the deterioration of the intestinal environment causes leaky gut and even affects the nervous system.<\/p>\r\n\r\n\r\n\r\n<p>Intestinal flora transplantation is one of the ways to improve the intestinal environment.<\/p>\r\n\r\n\r\n\r\n<p>&nbsp;<\/p>\r\n\r\n\r\n\r\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"i-3\"><\/span>FMT EFFECTIVE IN CARBAPENEM-RESISTANT BACTERIAL INFECTIONS AFTER KIDNEY TRANSPLANTATION<span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n\r\n\r\n\r\n<p>After an organ transplant, antibiotics are inevitably used.<br \/>This is important to prevent infection and to avoid endangering life.<\/p>\r\n\r\n\r\n\r\n<p>However, it is possible for bacteria resistant to antibiotics to proliferate and become infectious in their own right.<\/p>\r\n\r\n\r\n\r\n<p>This report describes the case of a 37-year-old woman.<br \/>She had received a kidney transplant, but a month after the operation she contracted Klebsiella pneumoniae infection, which is resistant to carbapenem antibiotics.<\/p>\r\n\r\n\r\n\r\n<p>THE PATIENT UNDERWENT FMT, AND A WEEK LATER HE WAS NEGATIVE FOR CARBAPENEM-RESISTANT KLEBSIELLA, AND 17 DAYS LATER HE HAD COMPLETELY RECOVERED.<\/p>\r\n\r\n\r\n\r\n<p>The diversity of her intestinal bacteria also recovered rapidly, from one week, to three weeks, to two months.<\/p>\r\n\r\n\r\n\r\n<p>This is a very valuable report, although it is based on only one patient.<br \/>The effectiveness of FMT in diseases where only antibiotic-resistant bacteria can thrive has been shown worldwide by Clostridium difficile infections.<\/p>\r\n\r\n\r\n\r\n<p>THIS REPORT HAS QUICKLY OPENED UP THE POSSIBILITY OF USING FMT FOR THE TREATMENT OF OTHER RESISTANT BACTERIA.<\/p>\r\n\r\n\r\n\r\n<p>&nbsp;<\/p>\r\n","protected":false},"excerpt":{"rendered":"FMT relieves symptoms of Parkinson&#8217;s disease (Original) Evaluation of fecal microbiota transplantation in Parkinson&#8217;s disease patients wit [&#8230;].","protected":false},"author":1,"featured_media":10328,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[106,113,107],"tags":[114],"class_list":["post-10327","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","category-intestine-flora","category-fmt","tag-gut-bacteria-papers-and-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - 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