{"id":10418,"date":"2020-01-08T14:00:50","date_gmt":"2020-01-08T05:00:50","guid":{"rendered":"https:\/\/symdfmtcopro.wpenginepowered.com\/post\/10418"},"modified":"2020-01-08T14:00:50","modified_gmt":"2020-01-08T05:00:50","slug":"schizophrenia-male-in-his-40s-fecal-microbiota-transplantation-case-report","status":"publish","type":"post","link":"https:\/\/fmt-japan.org\/en\/post\/10418","title":{"rendered":"Schizophrenia, male in his 40’s -Fecal microbiota transplantation case report"},"content":{"rendered":"

<\/span>Case presentation: Male in his 40s, schizophrenia<\/span><\/h2>\n

<\/span>summary<\/span><\/h3>\nHe has been visiting a psychiatrist with a diagnosis of schizophrenia since he was about 20 years old, due to bullying in junior high and high school.\nHe has hallucinations (auditory hallucinations), paranoia, and sleep disturbances, and takes psychiatric medication.\nAfter the transplantation (6 times course), he had a temporary feeling of heaviness, irritability, and fatigue, and after the 4th transplantation, the transplantation solution was changed. The patient improved by changing the transplantation solution after the fourth transplantation.\nAt present, we diagnose that her mental condition has not changed after 6 transplants.\n\n
\n

<\/span>Basic Information<\/span><\/h3>\n\n\n\n\n\n
Patients :<\/td>\n50s Male<\/td>\n<\/tr>\n
Attending physician :<\/td>\nMedical Corporation Nizenkai Tanaka Clinic<\/i><\/a><\/td>\n<\/tr>\n
Medical institution in charge of transplantation :<\/td>\nMedical Corporation Nizenkai Tanaka Clinic<\/i><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\n
\n

<\/span>Information at the time of initial medical examination<\/span><\/h3>\n\n\n\n\n\n\n\n\n\n
Disease name :<\/td>\nschizophrenia<\/td>\n<\/tr>\n
At onset :<\/td>\naround 20 years old<\/td>\n<\/tr>\n
Transplant Purpose: To<\/td>\nDepressive symptoms (mood swings)\nIrritability, tantrums\nConstipation\nAllergies (food, pollen, chemicals, etc.)<\/td>\n<\/tr>\n
Chief complaint :<\/td>\nAuditory hallucinations, paranoia<\/td>\n<\/tr>\n
Medications being taken :<\/td>\nCurrently taking Sediel, Wipax, Valerin, Rivotril, Invega, Fenofibrate, Nexium, and Epadel<\/td>\n<\/tr>\n
Medical history :<\/td>\nAllergies, childhood asthma<\/td>\n<\/tr>\n
Background, family history, lifestyle, supplement use, etc :<\/td>\nLives separately from his\/her family. He goes to a work shop. He plays futsal once a week. He is fed rice, miso soup, fermented foods, and vegetables when he comes back to his parents’ house (from his mother).\nHe has bowel movements every day. He smokes 15 cigarettes\/day. He sometimes eats junk food such as cup noodles at night.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\n
\n

<\/span>Transplant Information<\/span><\/h3>\n\n\n\n\n
Transplantation period: from<\/td>\nTransplantation period: from August 28, 2019 – October 8, 2019<\/td>\n<\/tr>\n
Number of transplants :<\/td>\n6 times<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\n
\n\n\n\n\n
Change from first transplant to end of transplant :<\/td>\n<\/tr>\n
At the end of the third session, symptoms worsened (fatigue, irritability, and a feeling of heaviness), so the transplanted bacterial solution was changed.\nAfter that, the patient became calm, but did not recover well.\n\u30101st transplantation questionnaire\u3011\nShe had constipation and took Mg oxide (330) 3T for 3 minutes after every meal, and her stools became a little softer. She was irritable, so she took Rivotril the day before and had a hard time waking up this morning.\n\uff1cDoctor’s note\uff1e\u21d2Mg oxide should not be excessive.\n\u30102nd transplantation questionnaire\u3011\nMood swings are the same. He tends to have a tendency to drag his mind back to the past. Today he has diarrhea.\n\uff1cDoctor’s note\uff1e\u21d2 Train your mind to shut out the past. Blood test before FMT was fine. After discussion, it was decided to continue with the change of the bacterial solution.\n\u30103rd transplantation questionnaire\u3011\nFeeling of breathlessness is getting stronger. Irritability. Tends to have insomnia at night. Bowel movements are improving.\n\u30104th transplantation questionnaire\u3011\nThe condition of her stools was better than before the FMT, and her atopy and asthma were also improving, but she became more irritable and felt heavy and heavy, and wanted to discontinue the FMT.\n\u30105th transplantation questionnaire\u3011\nThe day after the last FMT (2 weeks ago), she was feeling good, but after that, she became irritable and her fatigue became worse than ever. Even after exercise, he has a different lassitude than before. Constipation has improved compared to before.\n\u30106th transplantation questionnaire\u3011\nAfter the last transplant, her mood is better than before. However, the day after she felt depressed, she took a homeopathic remedy to calm down, and her mood has been stable since then. Sometimes, he eats a nighttime meal and the next day becomes difficult. Her bowel movements are good.\n\u3010After the 6th transplantation\u3011\nSymptoms such as paranoia have not changed, but they are better than the first time. She has trouble sleeping and cannot get up until late in the morning.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n\n\n\n\n
Changes after completion of transplant :<\/td>\n<\/tr>\n
Now following<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\n
\n

<\/span>Evaluation and Discussion<\/span><\/h3>\n\n\n\n\n\n\n
Transplant Evaluation :<\/td>\nNo change<\/td>\n<\/tr>\n
Pre- and post-transplant flora balance test changes :<\/td>\nIn the second session, the intestinal flora balance has changed significantly compared to the first session.\nIn the third visit, the diversity of intestinal flora has improved and symptoms are improving accordingly.<\/td>\n<\/tr>\n
Blood test changes :<\/td>\nnone in particular<\/td>\n<\/tr>\n
POMS2 SCORE CHANGE :<\/td>\nSlightly worse than the first<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\n< Intestinal flora balance 1st data >\"\"\n\n\uff1cIntestinal flora balance before transplant data\uff1e\n\"\"\n\n\uff1cIntestinal flora balance Post-transplant data\uff1e\n\"\"\n\n
\n\n\n\n\n
His\/her experience (from the questionnaire) :<\/td>\n<\/tr>\n
Symptoms of paranoia remain the same, but may be better than they were at first. Sleep disturbances are still present (difficulty getting up in the morning).<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\n
\n\n\n\n\n
Adverse events: No<\/td>\n<\/tr>\n
Nothing<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\n
\n\n\n\n\n
Transplant General Comments and Discussion :<\/td>\n<\/tr>\n
No effect of transplantation was seen. The symptoms improved by changing the transplantation solution, although there was a temporary worsening of the disease. However, it cannot be said that it was more effective than before transplantation.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\n… and upwards\n\n
\n\nReturn to Top of Case Studies<\/i><\/a>","protected":false},"excerpt":{"rendered":"Case presentation: Male in his 40s, schizophrenia summary He has been visiting a psychiatrist with a diagnosis of schizophrenia since he was about 20 years old, due to bullying in junior high and high school. He has hallucinations (auditory hallucinations), paranoia, and sleep disturbances, and takes psychiatric medication. After the transplantation (6 times course), he […]","protected":false},"author":1,"featured_media":10041,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[109],"tags":[86],"class_list":["post-10418","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-fmt_cases","tag-medical-corporation-jinzenkai-tanaka-clinic"],"acf":[],"yoast_head":"\nSchizophrenia, male in his 40's -Fecal microbiota transplantation case report - \u8178\u5185\u30d5\u30ed\u30fc\u30e9\u79fb\u690d\u81e8\u5e8a\u7814\u7a76\u4f1a<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fmt-japan.org\/post\/4861\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Schizophrenia, male in his 40's -Fecal microbiota transplantation case report - \u8178\u5185\u30d5\u30ed\u30fc\u30e9\u79fb\u690d\u81e8\u5e8a\u7814\u7a76\u4f1a\" \/>\n<meta property=\"og:description\" content=\"Case presentation: Male in his 40s, schizophrenia summary He has been visiting a psychiatrist with a diagnosis of schizophrenia since he was about 20 years old, due to bullying in junior high and high school. 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