{"id":10429,"date":"2019-08-07T11:13:18","date_gmt":"2019-08-07T02:13:18","guid":{"rendered":"https:\/\/symdfmtcopro.wpenginepowered.com\/post\/10429"},"modified":"2019-08-07T11:13:18","modified_gmt":"2019-08-07T02:13:18","slug":"pervasive-developmental-disorder-5-year-old-boy-fecal-microbiota-transplantation-case-report","status":"publish","type":"post","link":"https:\/\/fmt-japan.org\/en\/post\/10429","title":{"rendered":"Pervasive Developmental Disorder 5-year-old boy -Fecal microbiota transplantation case report"},"content":{"rendered":"

<\/span>Case presentation: 5-year-old boy, pervasive developmental disorder<\/span><\/h2>\n

<\/span>summary<\/span><\/h3>\nPurpose of autism improvement. A case in which stool characteristics, impulsivity, and hyperactivity were greatly improved after transplantation, but cognitive function remained unchanged.\n\n
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<\/span>Basic Information<\/span><\/h3>\n\n\n\n\n\n
Patients:.<\/td>\n5 years old, boy<\/td>\n<\/tr>\n
Attending physician:.<\/td>\nLuke’s Ashiya Clinic<\/i><\/a>\nHaruna Clinic<\/i><\/a><\/td>\n<\/tr>\n
Medical institution in charge of transplantation:.<\/td>\nHaruna Clinic<\/i><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\n
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<\/span>Information at the time of initial medical examination<\/span><\/h3>\n\n\n\n\n\n\n\n\n\n
Disease name:.<\/td>\npervasive developmental disorder<\/td>\n<\/tr>\n
At onset<\/td>\nnewborn baby<\/td>\n<\/tr>\n
Transplant Purpose: To<\/td>\nImprovement of pervasive developmental disorders<\/td>\n<\/tr>\n
Chief complaint:.<\/td>\nautistic<\/td>\n<\/tr>\n
Medications being taken:.<\/td>\nTaking Tafmac and Biosly tablets<\/td>\n<\/tr>\n
Medical history<\/td>\nNothing<\/td>\n<\/tr>\n
Background, family history, lifestyle, supplement use, etc.:.<\/td>\nVitamin B, vitamin D3, NAC, alpha lipoic acid, zinc, L-tryptophan, high blood pressure (grandfather), asthma (grandmother)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\n
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<\/span>Transplant Information<\/span><\/h3>\n\n\n\n\n
Transplantation period: from<\/td>\nNovember 1, 2018 – January 10, 2019<\/td>\n<\/tr>\n
Number of transplants<\/td>\n6 times<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\n
\n\n\n\n\n
Change from first transplant to end of transplant:.<\/td>\n<\/tr>\n
\u30101st transplantation questionnaire\u3011\nHer stools are good. He talks to me well. He understands well and looks me in the eye.\n\n
\n\n\u30102nd transplantation questionnaire\u3011\nHer personality seems to have become a little more aggressive. After stool transplantation, he had no bowel movement including bacterial fluid for 2 days, but after that, he had a soft stool once every 2 days.\n\n
\n\n\u30103rd transplantation questionnaire\u3011\nNo bowel movement for 1 day after transplantation. Bowel movements tended to be sluggish.\n\n
\n\n\u30104th transplantation questionnaire\u3011\nComprehension and language are increasing. Bowel movements are once every 2 days. Stools are improving.\n\n
\n\n\u30105th transplantation questionnaire\u3011\nWhile comprehension improves and calmness develops, there is no improvement in tantrums or motor skills. Bowel movements are every other day or two and of good consistency.\n\n
\n\n\u30106th transplantation questionnaire\u3011\nNo improvement in tantrums or movement ability.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n\n\n\n\n
Changes after completion of transplant:.<\/td>\n<\/tr>\n
The patient becomes more relaxed and conversational. Good bowel movements.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\n
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<\/span>Evaluation and Discussion<\/span><\/h3>\n\n\n\n\n\n\n
Transplant Evaluation:.<\/td>\nClear improvement of symptoms<\/td>\n<\/tr>\n
Pre- and post-transplant flora balance test changes:.<\/td>\n[BEFORE TRANSPLANT] PERFORMED IN OCTOBER 2018.\nFLORA BALANCE IS GOOD FOR AGE. THE ROOT OF SYMPTOMS IS NARROWED DOWN TO CLOSTRIDIUM 11.\n\n
\n\n[IMPLANTED] FEBRUARY 2019.\nCLOSTRIDIUM 11 IS DECREASED, AND IT IS PRESUMED THAT THE INFLAMMATION OF THE TISSUES RELATED TO BRAIN COMMAND IS SUBSIDED. SUGAR METABOLISM (IN THE BRAIN), WHICH UNTIL NOW HAD TO RELY ON BIFIDOBACTERIA, IS AIDED BY THE APPEARANCE OF THE GENUS PREVOTELLA, AND SUGAR IS NOW AVAILABLE TO THE BRAIN.<\/td>\n<\/tr>\n
Blood test changes:.<\/td>\n\uff3bAfter transplantation] None<\/td>\n<\/tr>\n
POMS2 SCORE CHANGE:.<\/td>\n\uff3bAfter transplantation] None<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\n\uff1cIntestinal flora balance before and after transplantation\uff1e\n\"\"
\n\n\n\n\n
His\/her experience (from the questionnaire):.<\/td>\n<\/tr>\n
Retrieved February 2019\nHe became calmer and able to talk. His stools are now of normal hardness.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \n\n\n\n\n
Adverse events: No<\/td>\n<\/tr>\n
Nothing<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \n\n\n\n\n
Transplant General Comments and Discussion:.<\/td>\n<\/tr>\n
Compared to before the implantation, his comprehension has increased and he is able to wait. His speech has become smoother than before with more words. His hyperactivity is decreasing, but his tantrums are uneven. She is no longer shy of her sister, and her bowel movements have improved since the fourth session.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

<\/span>Related Videos<\/span><\/h2>\nCASE STUDY: UB-FMT FOR AUTISM<\/strong>\nDr. Masahiko Shirotani, Director of Luke’s Ashiya Clinic, gave a presentation at the study session on March 9, 2019, based on actual cases of intestinal flora\n