{"id":10432,"date":"2019-07-31T16:31:59","date_gmt":"2019-07-31T07:31:59","guid":{"rendered":"https:\/\/symdfmtcopro.wpenginepowered.com\/post\/10432"},"modified":"2023-11-29T19:01:24","modified_gmt":"2023-11-29T10:01:24","slug":"irritable-bowel-syndrome-diarrhea-type-in-a-man-in-his-40s-case-report-of-fecal-microbiota-transplantation","status":"publish","type":"post","link":"https:\/\/fmt-japan.org\/en\/post\/10432","title":{"rendered":"Irritable bowel syndrome (diarrhea type) in a man in his 40s – Case report of fecal microbiota transplantation"},"content":{"rendered":"

<\/span>Case presentation: Male in his 40s, irritable bowel syndrome (diarrhea type)<\/span><\/h2>\r\n

<\/span>summary<\/span><\/h3>\r\n

A case of diarrhea (irritable bowel syndrome) that began a year and a half ago and continued until he came to our hospital after learning about stool transplantation on the Internet.<\/p>\r\n

\r\n

<\/span>Basic Information<\/span><\/h3>\r\n\r\n\r\n\r\n\r\n\r\n
Patients:.<\/td>\r\n40s Male<\/td>\r\n<\/tr>\r\n
Attending physician:.<\/td>\r\nKawai Internal Medicine Clinic<\/i><\/a><\/td>\r\n<\/tr>\r\n
Medical institution in charge of transplantation:.<\/td>\r\nKawai Internal Medicine Clinic<\/i><\/a><\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n
\r\n

<\/span>Information at the time of initial medical examination<\/span><\/h3>\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n
Disease name:.<\/td>\r\nIrritable bowel syndrome (diarrhea type)<\/td>\r\n<\/tr>\r\n
At onset<\/td>\r\nAround 42 years old<\/td>\r\n<\/tr>\r\n
Transplant Purpose: To<\/td>\r\nIrritable Bowel Syndrome Treatment<\/td>\r\n<\/tr>\r\n
Chief complaint:.<\/td>\r\nIrritable Bowel Syndrome Treatment<\/td>\r\n<\/tr>\r\n
Medications being taken:.<\/td>\r\nIlibo
\r\nMepenzotate
\r\nRohrazev
\r\nDepas
\r\nHange Shacintu (Chinese herbal medicine)<\/td>\r\n<\/tr>\r\n
Medical history<\/td>\r\nretinal detachment<\/td>\r\n<\/tr>\r\n
Background, family history, lifestyle, supplement use, etc.:.<\/td>\r\nMother (bladder cancer, high blood pressure, diabetes, heart disease), many supplements<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n
\r\n

<\/span>Transplant Information<\/span><\/h3>\r\n\r\n\r\n\r\n\r\n
Transplantation period: from<\/td>\r\nMay 29, 2018 – October 16, 2018<\/td>\r\n<\/tr>\r\n
Number of transplants<\/td>\r\n9 times<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n
\r\n\r\n\r\n\r\n\r\n
Change from first transplant to end of transplant:.<\/td>\r\n<\/tr>\r\n
\u30101st transplantation questionnaire\u3011
\r\nIrritable bowel syndrome for a year. had been carb free for 2 years until about Feb. Diarrhea did not get better. I do muscle training every day.<\/p>\r\n
\r\n

\u30102nd transplantation questionnaire\u3011
\r\nThe day after transplant, I had a banana stool. Diarrhea when taking protein in the morning.<\/p>\r\n

\r\n

\u30103rd transplantation questionnaire\u3011
\r\nSoft stools are continuing. No banana stools. Protein has been stopped.<\/p>\r\n

\r\n

\u30104th transplantation questionnaire\u3011
\r\nSome days I have good stools. I drink cold-pressed juice in the morning. 1 day I was constipated and had hard stools. I have had diarrhea for a long time, so I don’t take any dairy products. I can eat one egg a day, but if I eat two eggs a day, I get diarrhea. Eats pasta at night.<\/p>\r\n

\r\n

\u30105th transplantation questionnaire\u3011
\r\nShe seems to be doing well and is having mostly banana stools. He used to need to take Depas when entering a closed space such as boarding an airplane, but he was able to board the plane without it. He changed his breakfast to brown rice and stopped eating pasta.<\/p>\r\n

\r\n

\u30106th transplantation questionnaire\u3011
\r\nI have improved a lot since the 5th transplant. Recently, I have banana stools. I have diarrhea when I drink alcohol. I eat brown rice in the morning. I stopped eating pasta. I am mentally stable. I don’t need Depas before riding a train anymore.<\/p>\r\n

After the 6th transplant: I have maintained my condition after the 6th transplant. It worked dramatically. I don’t need Depas anymore. I have cut out wheat and dairy. I take vegetable juice and Supplement Lactis in the morning.<\/p>\r\n

\r\n

\u30107th transplantation questionnaire\u3011
\r\nI have been having banana stools. I am doing well, but I only have bowel movements almost as often as I eat. I want to eat once a day. I am cutting back on wheat.<\/p>\r\n

\r\n

\u30108th transplantation questionnaire\u3011
\r\nShe has been doing well since her last transplant. Normal stools this morning.<\/p>\r\n

\r\n

\u30109th transplantation questionnaire\u3011
\r\nNo diarrhea, banana-like stools with one bowel movement in the morning. She rarely consumes eggs and wheat, but eats natto and kimchi every day, and also consumes a lot of meat and rice.<\/p>\r\n<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n

\r\n\r\n\r\n\r\n\r\n
Changes after completion of transplant:.<\/td>\r\n<\/tr>\r\n
Symptoms showed almost complete improvement.<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n
\r\n

<\/span>Evaluation and Discussion<\/span><\/h3>\r\n\r\n\r\n\r\n\r\n\r\n\r\n
Transplant Evaluation:.<\/td>\r\nModerate improvement of symptoms<\/td>\r\n<\/tr>\r\n
Pre- and post-transplant flora balance test changes:.<\/td>\r\n\uff3bpre-transplant\uff3dThe lack of diversity in the flora is a result of eating what you want, doing what you want, and living a self-centered life, which has led to this balance.<\/p>\r\n

Although partial improvement can be expected from transplantation, mental reinforcement may be a priority for lasting relief.<\/p>\r\n

\r\n[Post-transplant] August 2018.<\/p>\r\n

The overall balance is markedly improved by diversification of Clostridium genus, improvement of the balance of Clostridium genus that controls the mental aspect, and increase of Lactobacillus group. If I may say so, if the ratio of bifidobacteria increases a little more, the genus Bacteroides will be able to perform its original functions such as production of organic acids, and I expect that both mental and physical symptoms will be further improved.<\/p>\r\n<\/td>\r\n<\/tr>\r\n

Blood test changes:.<\/td>\r\n\uff3bAfter transplantation] None<\/td>\r\n<\/tr>\r\n
POMS2 SCORE CHANGE:.<\/td>\r\n\uff3bAfter transplantation] None<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n

\uff1cIntestinal flora balance before and after transplantation\uff1e
\r\n\"\"<\/strong>

\r\n\r\n\r\n\r\n\r\n
His\/her experience (from the questionnaire):.<\/td>\r\n<\/tr>\r\n
Retrieved August 2018
\r\nBefore the transplant, I was anxious about the pain and other symptoms such as catheter insertion. I became accustomed to that anxiety or discomfort at the time of transplantation as I went through the process, and my symptoms were mostly improved at the end of the transplantation.<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n

 <\/p>\r\n\r\n\r\n\r\n\r\n
Adverse events: No<\/td>\r\n<\/tr>\r\n
Nothing<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n

 <\/p>\r\n\r\n\r\n\r\n\r\n
Transplant General Comments and Discussion:.<\/td>\r\n<\/tr>\r\n
Her diarrhea symptoms almost disappeared after 6 transplants, and her mental symptoms, such as anxiety when riding in a vehicle, which had always been present, also disappeared. After 3 more transplants, the patient had normal stools once a day and showed excellent improvement.<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n

<\/span>Related Videos<\/span><\/h3>\r\n

Date: 18 October 2018
\r\nThe 2nd General Foundation for Intestinal Flora Transplantation Clinical Study Group General Meeting Case Presentation *Case 2
\r\nPresenter: Dr. Yuichi Kawai, Kawaichi Clinic of Internal Medicine, Kawaichi, Japan<\/p>\r\n