Contents
- Status of FMT Clinical Studies and Clinical Trials in Japan and abroad
- 2 2. paper on efficacy and safety of FMT for ASD in FMT
- 3 3. papers on renal disease in FMT or intestinal bacteria
- 4 4. Papers on inflammatory bowel disease in FMT or gut microbiota
- 5 5. Papers on cancer in FMT or intestinal bacteria
- 6 6. Other
1. STATUS OF FMT CLINICAL STUDIES AND CLINICAL TRIALS IN JAPAN AND OVERSEAS
1) FMT IN GENERAL
Of these, one advanced medical care B: "Fecal microbiota transplantation for recurrent Clostridioides difficile-associated diarrhea and enteritis".
https://www.shigamed.ac.jp/sites/default/files/202009/pressrelease_hunbenisyoku.pdf* U.S. and some other countries: 545
https://clinicaltrials.gov/ct2/results?cond=&term=FMT%E3%80%80&cntry=&state=&city=&dist=2) Autism Spectrum Disorders
* U.S. and other countries: 10
https://clinicaltrials.gov/ct2/results?cond=ASD&term=FMT&cntry=&state=&city=&dist=* Japan: 0
2. PAPER ON EFFICACY AND SAFETY OF FMT FOR ASD IN FMT
1) Dae-Wook Kang, James B. Adams, Devon M. Coleman, Elena L. Pollard, Juan Maldonado, Sharon McDonough-Means, J. Gregory Caporaso, Rosa Krajmalnik J. Gregory Caporaso, Rosa Krajmalnik-Brown.
Long-term benefit of Microbiota Transfer Therapy on autism symptoms and
gut microbiota.
Sci. Rep. (2019) 9:5821.
2) Ning Li , Hongyan Chen, Yi Cheng, Fenghua Xu, Guangcong Ruan, Senhong Ying,Wen Tang, Lu Chen, Minjia Chen, LinLing Lv, Yi Ping, Dongfeng Chen and Yanling Wei.
Fecal Microbiota Transplantation Relieves Gastrointestinal and Autism
Symptoms
by Improving the Gut Microbiota in an Open-Label Study.
Front. Cell. Infect. Microbiol. 2021 Oct 19;11:759435.
Sci. Rep. (2019) 9:5821.
3. PAPERS ON RENAL DISEASE IN FMT OR INTESTINAL BACTERIA
The following is a very recently Pressed review. It describes past attempts to treat renal disease with FMT.
* Ji Bian, Ann Liebert, Brian Bicknell, Xin-Ming Chen, Chunling Huang, Ji Bian, Ann Liebert, Brian Bicknell, Xin-Ming Chen, Chunling Huang, and Carol A. Pollock1, Faecal Microbiota Transplantation and Chronic Kidney Disease Nutrients. 2022 Jun; 14(12): 2528
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228952/4. PAPERS ON INFLAMMATORY BOWEL DISEASE IN FMT OR INTESTINAL BACTERIA
VERY RECENTLY, AN EXCELLENT REVIEW ARTICLE HAS BEEN PUBLISHED FROM CHINA. IN IT, ALL FMT-IBDS IN THE WORLD FROM THE PAST TO THE PRESENT ARE LISTED.
1) Raees Khan,1Nazish Roy, Hussain Ali, and Muhammad Naeem
Fecal Microbiota Transplants for Inflammatory Bowel Disease Treatment: Synthetic- and Engineered
Communities-Based Microbiota Transplants Are the Future
Gastroenterology Research and Practice, Volume 2022, Article ID 999999925, 9 pages
2) Xi-Yue Tan, Yu-Jia Xie, Xing-Long Liu, Xin-Yun Li, and Bo Jia
A Systematic Review and Meta-Analysis of Randomized Controlled Trials of Fecal Microbiota
Transplantation for the Treatment of Inflammatory Bowel Disease
Evidence-Based Complementary and Alternative Medicine, Volume 2022, Article ID 8266793, 14 pages
5. PAPERS ON CANCER IN FMT OR INTESTINAL BACTERIA
Intestinal bacteria and cancer have been linked, in part because they are both interrelated to the human immune system. Some studies have suggested that certain intestinal bacteria may hold the key, starting from the point where an imbalance in the intestinal microbiota may lead to the development and progression of cancer.
1) Review of the association between intestinal bacteria and cancer
Cheng WY, Wu CY, Yu J.
The role of gut microbiota in cancer treatment: friend or foe?
Gut. 2020;69(10):1867-1876. doi:10.1136/gutjnl-2020-321153
https://gut.bmj.com/content/69/10/1867
Helmink BA, Khan MAW, Hermann A, Gopalakrishnan V, Wargo JA.
The microbiome, cancer, and cancer therapy.
Nat Med. 2019;25(3):377-388. doi:10.1038/s41591-019-0377-7
https://www.nature.com/articles/s41591-019-0377-7
Schwabe RF, Jobin C.
The microbiome and cancer.
Nat Rev Cancer. 2013;13(11):800-812. doi:10.1038/nrc3610
https://www.nature.com/articles/nrc3610
2) REVIEW ON CANCER AND FMT
Chen D, Wu J, Jin D, Wang B, Cao H.
Fecal microbiota transplantation in cancer management: current status and perspectives.
Int J Cancer. 2019;145(8):2021-2031. doi:10.1002/ijc.32003
https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32003
Wardill HR, Secombe KR, Bryant RV, Hazenberg MD, Costello SP.
Adjunctive fecal microbiota transplantation in supportive oncology: Emerging indications and considerations in immunocompromised patients.
EBioMedicine. 2019;44:730-740. doi:10.1016/j.ebiom.2019.03.070
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603490/
6. other
The theory states that when bacteria and colloids coexist, as in the case in non-Newtonian fluids, the hydrodynamic interaction between bacteria and colloids suppresses the oscillation of intestinal bacteria and increases their motility, resulting in a larger migration distance. If we adopt this theory, we can consider that the intestinal bacteria have a greater probability of reaching the intestinal mucosa when coexisting with hydrogen nanobubble colloids.
1) References: The colloidal nature of complex fluids enhances
bacterial motility.
S.Kamdar et al., Nature, 603,819-823 (2022).
2) FMT for patients with advanced melanoma
Immune checkpoint inhibitor (ICI)" response rate improvement
Situation in the U.S.
https://clinicaltrials.gov/ct2/results?cond=cancer&term=FMT&cntry=&state=&city=&dist=
S.Kamdar et al., Nature, 603,819-823 (2022).
Immune checkpoint inhibitor (ICI)" response rate improvement
List of publications on intestinal bacteria worldwide (through 2020)
The following is a list of articles and summary articles with relatively high levels of evidence.
List of resources on Intestinal Bacteria and Immunity [Papers and Research Information]. List of resources on intestinal bacteria in general [Papers and research information]. Resource list of indigenous bacteria (oral, nasal, vaginal, and cutaneous) [Publications and research information]. List of resources on intestinal bacteria and various diseases [Papers and research information]. List of materials on fecal microflora transplantation [Papers and research information].*Papers from 2021 and beyond areList of articles in the Journal of Intestinal Microbiology for a list of articles from 2021 onward.
