Papers

2) Autism Spectrum Disorders

* U.S. and other countries: 10

https://clinicaltrials.gov/ct2/results?cond=ASD&term=FMT&cntry=&state=&city=&dist=

* Japan: 0

2. PAPER ON EFFICACY AND SAFETY OF FMT FOR ASD IN FMT

1) Dae-Wook Kang, James B. Adams, Devon M. Coleman, Elena L. Pollard, Juan Maldonado, Sharon McDonough-Means, J. Gregory Caporaso, Rosa Krajmalnik J. Gregory Caporaso, Rosa Krajmalnik-Brown.

Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota.
Sci. Rep. (2019) 9:5821.

https://www.nature.com/articles/s41598-019-42183-0

2) Ning Li , Hongyan Chen, Yi Cheng, Fenghua Xu, Guangcong Ruan, Senhong Ying,Wen Tang, Lu Chen, Minjia Chen, LinLing Lv, Yi Ping, Dongfeng Chen and Yanling Wei.

Fecal Microbiota Transplantation Relieves Gastrointestinal and Autism Symptoms by Improving the Gut Microbiota in an Open-Label Study.
Front. Cell. Infect. Microbiol. 2021 Oct 19;11:759435.
Sci. Rep. (2019) 9:5821.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560686/

3. PAPERS ON RENAL DISEASE IN FMT OR INTESTINAL BACTERIA

The following is a very recently Pressed review. It describes past attempts to treat renal disease with FMT.

* Ji Bian, Ann Liebert, Brian Bicknell, Xin-Ming Chen, Chunling Huang, Ji Bian, Ann Liebert, Brian Bicknell, Xin-Ming Chen, Chunling Huang, and Carol A. Pollock1, Faecal Microbiota Transplantation and Chronic Kidney Disease Nutrients. 2022 Jun; 14(12): 2528

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228952/

4. PAPERS ON INFLAMMATORY BOWEL DISEASE IN FMT OR INTESTINAL BACTERIA

VERY RECENTLY, AN EXCELLENT REVIEW ARTICLE HAS BEEN PUBLISHED FROM CHINA. IN IT, ALL FMT-IBDS IN THE WORLD FROM THE PAST TO THE PRESENT ARE LISTED.

1) Raees Khan,1Nazish Roy, Hussain Ali, and Muhammad Naeem
Fecal Microbiota Transplants for Inflammatory Bowel Disease Treatment: Synthetic- and Engineered

Communities-Based Microbiota Transplants Are the Future
Gastroenterology Research and Practice, Volume 2022, Article ID 999999925, 9 pages

https://downloads.hindawi.com/journals/grp/2022/9999925.pdf

2) Xi-Yue Tan, Yu-Jia Xie, Xing-Long Liu, Xin-Yun Li, and Bo Jia
A Systematic Review and Meta-Analysis of Randomized Controlled Trials of Fecal Microbiota

Transplantation for the Treatment of Inflammatory Bowel Disease
Evidence-Based Complementary and Alternative Medicine, Volume 2022, Article ID 8266793, 14 pages

https://pubmed.ncbi.nlm.nih.gov/35795291/

5. PAPERS ON CANCER IN FMT OR INTESTINAL BACTERIA

Intestinal bacteria and cancer have been linked, in part because they are both interrelated to the human immune system. Some studies have suggested that certain intestinal bacteria may hold the key, starting from the point where an imbalance in the intestinal microbiota may lead to the development and progression of cancer.

1) Review of the association between intestinal bacteria and cancer
Cheng WY, Wu CY, Yu J.
The role of gut microbiota in cancer treatment: friend or foe?
Gut. 2020;69(10):1867-1876. doi:10.1136/gutjnl-2020-321153
https://gut.bmj.com/content/69/10/1867
Helmink BA, Khan MAW, Hermann A, Gopalakrishnan V, Wargo JA.
The microbiome, cancer, and cancer therapy.
Nat Med. 2019;25(3):377-388. doi:10.1038/s41591-019-0377-7
https://www.nature.com/articles/s41591-019-0377-7
Schwabe RF, Jobin C.
The microbiome and cancer.
Nat Rev Cancer. 2013;13(11):800-812. doi:10.1038/nrc3610
https://www.nature.com/articles/nrc3610

2) REVIEW ON CANCER AND FMT
Chen D, Wu J, Jin D, Wang B, Cao H.
Fecal microbiota transplantation in cancer management: current status and perspectives.
Int J Cancer. 2019;145(8):2021-2031. doi:10.1002/ijc.32003
https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32003
Wardill HR, Secombe KR, Bryant RV, Hazenberg MD, Costello SP.
Adjunctive fecal microbiota transplantation in supportive oncology: Emerging indications and considerations in immunocompromised patients.
EBioMedicine. 2019;44:730-740. doi:10.1016/j.ebiom.2019.03.070
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603490/

6. other

The theory states that when bacteria and colloids coexist, as in the case in non-Newtonian fluids, the hydrodynamic interaction between bacteria and colloids suppresses the oscillation of intestinal bacteria and increases their motility, resulting in a larger migration distance. If we adopt this theory, we can consider that the intestinal bacteria have a greater probability of reaching the intestinal mucosa when coexisting with hydrogen nanobubble colloids.

1) References: The colloidal nature of complex fluids enhances bacterial motility.
      S.Kamdar et al., Nature, 603,819-823 (2022).

2) FMT for patients with advanced melanoma
 Immune checkpoint inhibitor (ICI)" response rate improvement

Situation in the U.S.

https://clinicaltrials.gov/ct2/results?cond=cancer&term=FMT&cntry=&state=&city=&dist=