No.5 Introduction of Recent Papers on Microbiome Research (Frontiers of Microorganisms and Intestinal Bacteria)

In the early days, papers on associations between bacterial face (species) and disease were prominent, but recently, many studies seem to focus on metabolism (function) and transcriptome.

With genomic analysis technology readily available, the number of publications on the invisible microbiome, or gut bacteria, has increased exponentially over the past decade or so.

Here we regularly present articles collected from PubMed using keywords such as ‘gut microbiome’ ‘FMT’.

On the one hand, it is dangerous to rely on new papers, as they have not yet been evaluated, and on the other hand, they give us access to the frontiers of research.
We encourage you to read the main points that interest you, even if only to the point!

Table of Contents

1. Examine gut bacteria trends in metabolically healthy obese individuals from anthropometric, metabolic, and inflammatory variables
2. Crosstalk between microbial metabolism and host immunity: relevance to allergic diseases
3. Colorectal Cancer Development in Young Adults Associated with the Gut Microbiome, Environment, and Diet
4. In in vitro experiments, supplemented formula and breast milk show similar patterns in gut bacteria composition and function
5. Multi-omics analysis reveals correlations between gut microbiome, host genome, and transcriptome in colorectal cancer patients
6. ↓その他にもこんな論文がありました。
   (1)腸からホルモンへ： 健康と病気における（植物）エストロゲン調節における腸内細菌叢の役割を解明する
   (2)土壌暴露はマウスモデルにおけるインフルエンザチャレンジに対する免疫応答を調節する
   (3)自閉症スペクトラム障害における腸内細菌叢と血清アミノ酸メタボロームの変化
   (4)抗菌マウスウォッシュは腸内細菌叢を変化させ、西洋食飼育マウスの栄養吸収と脂肪蓄積を低下させる
   (5)オランダ人と南アジア系スリナム人の腸内細菌叢の違い：2型糖尿病への潜在的影響

1. examine gut bacterial trends in metabolically healthy obese individuals from anthropometric, metabolic, and inflammatory variables

Gut microbiome signature of metabolically healthy obese individuals according to anthropometric, metabolic and inflammatory parametersIn this study, we investigated the characteristics of gut micwww.ncbi.nlm.nih.gov

[Regular Article]
(Title) Gut microbiome signature of metabolically healthy obese individuals according to anthropometric, metabolic and inflammatory parameters
（Gut microbiome signature of metabolically healthy obese individuals according to anthropometric, metabolic and inflammatory parameters
（Abstract: Fecal samples were collected and m16S rDNA sequenced from 120 metabolically healthy obese adults. Clinical typing, metabolic and inflammatory values were analyzed simultaneously. They were divided into types 1 and 2. The type 1 gut bacteria were predominantly Prevotellidae, with high serum interleukin levels and decreased gut bacterial diversity observed. Their feces also contained a large number of extracellular vesicles derived from the genus Prevotella, and fewer Actinobacteria, Firmicutes, Proteobacteria, Ackermansia, and Bacteroidetes.
(Authors) Ho-Kyoung Lee et al.
Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173, Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13620 South Korea
(Journal Title) SCIENTIFIC REPORTS
(Date of Publication) 2024 Feb 11
(Comment) Although it is difficult to say at this point which type is more important, it may be said that obese people who appear to be medically healthy can be divided into two types: those in an unwell state and those in a healthy state.

2. Crosstalk between microbial metabolism and host immunity: relevance to allergic diseases

A cross talk between microbial metabolites and host immunity: Its relevance for allergic diseasesAllergic diseases, including respiratory and food allergies,www.ncbi.nlm.nih.gov

[Review Article]
（タイトル）A cross talk between microbial metabolites and host immunity: Its relevance for allergic diseases
（タイトル訳）微生物の代謝と宿主の免疫間のクロストーク：アレルギー性疾患に関連して
（概要）アレルギー疾患に腸マイクロバイオームの乱れが関連していることが判明しつつある状況を踏まえ、腸内細菌の代謝が宿主の免疫機能やその代謝に及ぼす影響を、恒常性やアレルギー疾患をからめてレビューした文献。短鎖脂肪酸、アミノ酸、胆汁酸などの微生物による代謝と免疫細胞細胞との関係を詳しく解説している。
（著者）Purevsuren Losol
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam Korea
Milena Sokolowska
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos Switzerland
ほか
（雑誌名・出版社名）Clin Transl Allergy
（出版日時）2024 Feb 11
（コメント）細菌の顔ぶれそのものではなく、その代謝物と疾患の関係をレビューしている

3. association of the gut microbiome, environment, and diet with the development of colorectal cancer at a young age.

The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer DevelopmentPopulation statistics from recent years have demonstrated thawww.ncbi.nlm.nih.gov

[Review Article]
(Title) The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer Development
（The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer Development
（Abstract: This article provides a comprehensive overview of the impact of the gut microbiome, the environment, diet, and host factors that influence the gut microbiome in young patients with colorectal cancer.
(Authors) Rui Dai et al.
Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
(Journal name/Publisher) cancers(MDPI)
(Date of Publication) 2024 Feb 5
(Comment) This article summarizes the current status and discusses future prospects for the early detection and treatment of colorectal cancer that develops in patients under 50 years of age.

4. In in vitro experiments, supplemented formula and breast milk show similar patterns in gut bacterial composition and function

Supplemented Infant Formula and Human Breast Milk Show Similar Patterns in Modulating Infant Microbiota Composition and Function In VitroThe gut microbiota of healthy breastfed infants is often domiwww.ncbi.nlm.nih.gov

[Regular Article]
(Title) Supplemented Infant Formula and Human Breast Milk Show Similar Patterns in Modulating Infant Microbiota Composition and Function In Vitro
（Supplemented Infant Formula and Human Breast Milk Show Similar Patterns in Modulating Infant Microbiota Composition and Function In Vitro
(Abstract) Using the INFOGEST method, this study examines how formula supplemented with ingredients that mimic breast milk, regular formula, and breast milk differ in bacterial composition and short-chain fatty acid production. Although only in vitro, the supplemented formula resulted in a bacterial composition and short-chain fatty acid production capacity that was comparable to breast milk. Note, however, that it is not identical to breast milk.
(Authors) Klaudyna Borewicz et al.
Mead Johnson B.V., Middenkampweg 2, 6545 CJ Nijmegen, The Netherlands
（International Journal of Molecular Sciences (MDPI)
(Date of Publication) 2024 Feb 2
(Comment) Milk powder manufacturers are also focusing on microorganisms for development. The Netherlands, where the author belongs to, seems to be a leading country in the development of powdered milk manufacturers.

5. Multi-omics analysis reveals correlations between gut microbiome, host genome, and transcriptome in colorectal cancer patients

Multi-omic profiling reveals associations between the gut microbiome, host genome and transcriptome in patients with colorectal cancerColorectal cancer (CRC) is the leading cancer worldwide. Micr www.ncbi.nlm.nih.gov

[Regular Article]
(Title) Multi-omic profiling reveals associations between the gut microbiome, host genome and transcriptome in patients with colorectal cancer
（Multi-omic profiling reveals associations between the gut microbiome, host genome and transcriptome in patients with colorectal cancer
(Abstract) Genomic and transcriptomic analyses were performed on the fecal microbiota of 41 colorectal cancer patients and tissues collected from tumor-bearing and non-tumor-bearing areas.
As a result, 22 microbial associations were identified, and four additional genes were associated with cancer-associated microorganisms. Among them, Fusobacterium nucleatum was found to alter the tumor immune environment. These results suggest that multi-omics analysis may be useful for diagnosis.
(Authors) Shaomin Zou et al.
Department of General Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510655 China
（Journal of Translational Medicine
(Date of Publication) 2024 Feb 18

6.↓Other papers like this one.

(1)From Gut to Hormones: Unraveling the Role of Gut Microbiota in (Phyto)Estrogen Modulation in Health and Disease

https://pubmed.ncbi.nlm.nih.gov/38342595/#full-view-affiliation-1

(Comment) How the gut microbiome is involved in estrogen and equol production. Paid Papers.

(2)Soil exposure modulates the immune response to an influenza challenge in a mouse model

https://pubmed.ncbi.nlm.nih.gov/38340827/

(Comment) To test the “old friend hypothesis”, we are observing the gut & lung microbiome before and after exposing mice to soil microbes and then infecting them with influenza.

(3)Gut microbiome and serum amino acid metabolome alterations in autism spectrum disorder

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10874930/

(Comment) Comparative study of gut microbiota and serum amino acid metabolites in 30 ASD patients and typically developing children.

(4)Antibacterial mouthwash alters gut microbiome, reducing nutrient absorption and fat accumulation in Western diet-fed mice

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10874955/

(Comment) Suggests that antimicrobial mouthwash may disrupt the gut microbiome over the long term and interfere with nutrient absorption.

(5)Differences in gut microbiota between Dutch and South-Asian Surinamese: potential implications for type 2 diabetes mellitus

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10894869/

(Comment) Comparing the gut microbiota of the Dutch and the South Asian Surinamese, a minority ethnic group, this study explores the relationship between the microbiota and susceptibility to type II diabetes mellitus.