Dysautonomia, Menopausal Disorder, Female in her 40s -Fecal Microflora Transplantation Case Report
Case presentation: Female in her 40s, autonomic ataxia, menopausal disorders
summary
Since meniscus knee surgery, I have been feeling tense and unsettled. He feels well in the morning, but becomes worse in the late afternoon and evening. At night she feels fine. Her bowel movements are not clear with a feeling of residual bowel movements. She has little appetite, especially during menstruation and ovulation. Sleep is shallow, palms are sweaty, and sympathetic nervous system is tense.
After 3 transplants, fatigue is almost gone and bowel movements are better. His appetite has also increased.
Since the completion of the fifth transplant, he no longer feels depressed and his physical condition is good despite the humid climate of the rainy season. I would like to continue to have additional transplants to maintain my physical condition, though irregularly.
Basic Information
| Patients:. | Woman in her 40s |
| Attending physician:. | Medical Corporation Haruna Clinic |
| Medical institution in charge of transplantation:. | Medical Corporation Haruna Clinic |
Information at the time of initial medical examination
| Disease name:. | Dysautonomia, menopausal disorders |
| At onset | October 2018 |
| Transplant Purpose: To | Improvement of disease and sleep disorders |
| Chief complaint:. | One month after the left meniscus replacement surgery, I began to feel fidgety, nervous, and restless. She was also unable to sleep. This coincided with menopause due to a drop in female hormones, and overall, she began to experience mood swings, fatigue, sleep disturbances, and sympathetic nervous tension. For several decades, she had been constipated unless she took laxatives, but by taking lactobacillus supplements, she began to have stools every day. In order to improve these symptoms, she wishes to have an intestinal flora transplant. |
| Medical history | September 2018 left knee meniscus surgery |
| Background, family history, lifestyle, supplement use, etc.:. | Chinese herbal medicine, supplements |
Transplant Information
| Transplantation period: from | 2019/07/09~2023/04/06 |
| Number of transplants | 3 transplants + 11 additional transplants |
| Change from first transplant to end of transplant:. |
| [Interview at the time of the 1st transplant] (From the patient) I feel well in the morning, but I have a strong sense of fatigue from late afternoon to evening. At night, she feels better. She has a bowel movement every day, but there is a feeling of residual feces, and her stomach feels tight. Wounds are difficult to heal. (Interview at the time of the second transplant) (From the patient) Emotionally, there has been no significant change. I feel like I am sleeping more deeply. I used to force myself to eat even if I didn’t feel hungry, but now I feel hungry and can eat. No bacterial fluid was produced after transplantation, and normal stools were produced the next day. [Interview at the time of the third transplant] (From the patient) After the second transplant, no bacterial fluid was produced and all was absorbed. Her bowel movements are getting better, but her stomach is a little tense once every two days. The premenstrual tummy tightness is gone. I still feel sluggish in the evening, but I feel a little better. I am able to sleep soundly now. (Interview 3 months after transplantation) (From the patient) Visited the clinic for an examination 3 months after the transplantation. Her mood swings have improved after the transplant and her appetite has increased. She feels sound sleep and is sleeping well. She still feels fatigue during menstruation and ovulation. In addition to the 3-transplant course, she wishes to have 3 additional transplants. Interview at the time of the 4th (additional 1) transplant] (From the patient) Her mood swings, anxiety, and fatigue have improved considerably. [5th (Additional 2) Interview at the time of transplantation] The patient wants to prevent mental instability caused by menopause and to improve her metabolism. According to the patient, she always has severe hay fever, but this year her hay fever symptoms were not so severe. She also said that she feels mentally stable. [6th (Additional 3) Interview at the time of transplantation] (From the patient) After the transplantation, the bacteria fluid has been absorbed without any discharge. Since the transplantation, the patient has become mentally stable with little or no depression. The patient would like to have several more transplants in the future, with intervals in between. [7th (Additional 4) Interview at the time of transplantation] The patient has anxiety neurosis and sometimes becomes anxious, but the anxiety does not continue all the time as it did before, so he has become mentally stable. [8th (Additional 5) Interview at the time of transplantation] (From the patient) Mentally, I am stable and in good shape. [Interview at the time of the 9th (additional 6) transplant] (From the patient) Since the additional transplant, I have become mentally calmer after each transplant. [Interview at the time of the 10th (Additional 7) transplant] (From the patient) I am mentally stable. I am able to maintain it through regular transplantation. I think the current bacterial solution suits me. 11th (Additional 8) Interview at the time of transplantation] (From the patient) I visited my local doctor because of persistent diarrhea. The diarrhea became worse after being given antibiotics. He was admitted to the hospital on suspicion of pseudomembranous enteritis, but was diagnosed with ulcerative colitis. The diarrhea has now subsided. She came to the hospital today and her symptoms are stable without any abdominal symptoms. [12th (Additional 9) Interview at the time of transplantation] (From the patient) The ulcerative colitis has settled down now. Her bowel movements are not bad. No bloody stools. She is mentally much more comfortable than before, and she is able to sleep at night without anxiety. [13th (Additional 10) Interview at the time of transplantation] (From the patient) The ulcerative colitis has calmed down. I feel better now that I have gas. I felt better after the previous transplant, but I think the current bacterial solution is right for my intestines. [Questionnaire at the time of the 14th (Additional 11) transplant] (From the patient) I feel very well. My stomach feels good and I am mentally calm. |
Intestinal flora balance Comparative data
| His/her experience (from the questionnaire):. | No answer |
Evaluation and Discussion
| Transplant Evaluation:. | Moderate improvement of symptoms |
| Adverse events: No | Nothing |
| Changes after completion of transplant:. |
| He has become moodier, brighter, and more mentally stable. He hopes to have additional transplants at irregular intervals in the future. The transplantation has given her a sense of mental stability. In addition, her appetite has increased as well as her bowel movements have improved, suggesting that the change in her intestinal environment has helped improve her mental health. In the future, she would like to control her metabolism as she is experiencing menopausal symptoms and weight gain. |
| Transplant General Comments and Discussion:. |
| Mentally he is quite stable and wants to have regular transplants. He said that the current fungal solution suits him very well. |
… and upwards
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