Autism Spectrum Disorder 6-year-old boy -Fecal microbiota transplantation case report
Case presentation 6-year-old boy with autistic spectrum disorder
summary
A case of fecal microbiota transplantation for a patient with autism spectrum disorder (ASD). He used to put everything in his mouth, but immediately after the transplantation, he stopped doing so, and the number of situations in which he could tolerate the food increased. The concept of ownership was formed, and communication between parents and children became smoother. This case is considered to be an effect of the transplantation.
Basic Information
| Patients : | 6 year old boy |
| Attending physician : | Luke’s Ashiya Clinic |
| Medical institution in charge of transplantation : | Luke’s Ashiya Clinic |
Information at the time of initial medical examination
| Disease name : | ASD |
| Time of onset : | February 2017 |
| Transplant Purpose: To | Improvement of disease |
| Chief complaint : | Constipation disorder, defecation every 2 or 3 days. Atopic dermatitis with recurrent itchy scabs at 3 months of age, itching, eczema, and redness of skin at over 2 years of age. Currently, she is improving with bone broth. Autism was characterized by constant behaviors, lack of eye contact, and inability to understand when I called his name or spoke to him. Currently, he can understand simple words but is unable to communicate. He is trusting and sweet to adults, but shows little interest in children. Tantrums have disappeared. He refuses to enter new places, especially private rooms and examination rooms, but once he is forced to enter, he does not show any signs of reluctance. |
| History: | Nothing |
| Background, family history, lifestyle, supplement use, etc : | Allelock OD tablet (morning and evening) Itching all over the body: mixture of Restamine, Eulax, and Azunor (morning and evening) Heparin-like foam spray (morning and evening) |
Transplant Information
| Transplantation period: from | 2023/8/23〜2023/9/28 |
| Number of transplants : | 6 transplants |
| Change from first transplant to end of transplant : |
| [At the time of the first transplant]. She understands language to some extent, but she does not speak much and does not call people spontaneously. She can clearly sing the music of “Okasan to tokuso,” but she does not understand the meaning of the lyrics. At the time of the first transplant interview, there was no speech. No facial expression. Weak abdominal rumbling. Immediately after transplantation, a small amount of bacterial fluid was discharged, and 20 minutes later, a small amount of fluid was also discharged when the patient stood up. Transplantation went smoothly. During position change after transplantation, there was a sudden laughing behavior. The patient said that she has this behavior at home as well. At the time of the second transplant The morning of the day after the first transplant, there was a rash all over the body. It disappeared the day after. No itching. After transplantation, stools became Type 4. During the third transplant During the insertion of the catheter for the third time, the patient made a disgusted voice, but followed the instructions and the transplantation went smoothly. Occasionally, their eyes met. She seemed to feel a change in her stool condition after the transplant. [During the fourth transplant]. He was expressionless, but had occasional smiling gestures. She followed instructions and the transplant went smoothly. According to his mother, his speech had somewhat decreased. She used to talk when I miked her hand. Eye contact was good. When we went to the park, he started to look for his mother, which he said was the first time he had ever done so. She also started to tell us when she had to go to the bathroom while playing. During the 5th transplant During a position change after the 5th transplant, there was urination. She said, “Ah, ah! She had never felt embarrassed before, but this time she was talking and seemed to have some feelings. [At the 6th transplant After the 4th transplant, until the 6th transplant, she had a good stomach rumbling, was in a good mood, and had more opportunities to make eye contact. |
| Changes after completion of transplant : |
| They don’t look at each other, but they sit still and receive medical examinations. Sometimes they look at each other. I am now cooler than I was before. No more unnecessary voice leaks. He laughs when he remembers. The primitive reflex to put everything in my mouth disappeared. The original impulsivity has begun to settle down. He did not suddenly start running around town or hold my hand, but he started trying to hold my hand throughout the walk. …Shyness is coming out. The patient is now able to wait. These changes have made it easier for the family (especially the mother), but the transplant has reduced the burden on the family. Tends to be constipated. She has been having a bowel movement every other day since the 6th transplant. During the 18-week interview, the procedure was performed smoothly in response to our calls, although eye contact was not made. The last time I saw him, he seemed cool, but his personality came more to the forefront and he didn’t like it as much. I can see that they are trying to communicate with each other. I can see that he is trying to communicate somehow. His father also feels the change, and a school teacher pointed out that he has an increased smiling face, giving the impression that his growth has been boosted by the transplant. After implantation, the stools were like adult stools with a strong smell for a while, but after 30 weeks, the stools became like a child’s original feces. The smell is not bothersome. Sausage-like stools are being produced. ∙ When he was alone, he began to feel alienated. The way she cries is like a child. He had a farewell ceremony, but was able to spend the time without voice leakage. He was hearing-dominant and did not like the sound of gagaku and ran away. …This year I could not get frostbite. He was calm at the 30 week interview. During the Gaze Finder measurement, he always looked away when the woman’s face was large. Measurements are taken while sitting on her lap with her mother due to her body movements. Vital measurements were smooth. Blood pressure measurement was anxious, but she was able to hold still. |
Intestinal flora balance Comparative data
Evaluation and Discussion
| Transplant General Comments and Discussion : |
| Before the transplant, he lacked interest in and attachment to others, but after the transplant, he became more attached to his mother and increased his skinship. He was not afraid of being alone in his room, but after the transplant, he became able to understand his surroundings and became lonely when alone. It is thought that the transplantation procedure may have helped her to develop an ego and to recognize the differences between herself and others. |
… and upwards
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Fecal microbiota transplantation results *As of September , 2025
The number of actual fecal microbiota transplants by case in our study group is as follows Case reports by disease You can view case reports by disease from the links below: [Ulcerative Colitis]https://fmt-japan.org/research-activities/fmt-cases-index?tag=uc [Irritable Bowel Syndrome]https://fmt-japan.org/research-activities/fmt-cases-index?tag=ibs [Atopic Allergies]https://fmt-japan.org/research-activities/fmt-cases-index?tag=allergy [Constipation]https://fmt-japan.org/research-activities/fmt-cases-index?tag=constipation [ASD (Autism Spectrum Disorder)]https://fmt-japan.org/research-activities/fmt-cases-index?tag=asd [Other Diseases]https://fmt-japan.org/research-activities/fmt-cases-index?tag=others
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Case presentation 12-year-old girl with autistic spectrum disorder summary A case of transplantation for autistic spectrum disorder. Improvement in bowel movements, sleep quality, and tantrums were observed, but not much change was seen in the hyperactivity aspect or impulsivity. Basic Information Patients :12-year-old girlAttending physician :Luke’s Ashiya ClinicMedical institution in charge of transplantation :Luke’s Ashiya […]
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6-year-old boy with autism spectrum disorder -Fecal microbiota transplant case report
Case presentation 6-year-old boy with autistic spectrum disorder summary A case of transplantation for autism spectrum disorder (ASD). The patient has difficulty in understanding his surroundings and tends to be hyperactive. The main complaint was lack of concentration. No significant change was observed after transplantation. Basic Information Patients :6 year old boyAttending physician :Luke’s Ashiya […]
