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Parkinson’s disease, male in his 70s (ongoing)-Fecal microbiota transplantation case report

Case presentation Male in his 70s, Parkinson’s disease (ongoing)

summary

First visit on February 15, 2018. About a year ago, she began to have increased tremor in her limbs, body movements, and inability to get enough sleep at night. The tremor is stronger when he is nervous. She tends to be constipated and has bowel movements with Chinese herbal medicine. (As an interim evaluation)

Basic Information

Patients:. 70s Male
Attending physician:. Tanaka Clinic
Medical institution in charge of transplantation:. Tanaka Clinic

Information at the time of initial medical examination

Disease name:. Other Diseases
At onset Around 75 years old
Transplant Purpose: To Symptom improvement
Chief complaint:. trembling or shaking of the limbs
Medications being taken:. glutathione
Medical history unknown
Background, family history, lifestyle, supplement use, etc.:. unknown

Transplant Information

Transplantation period: from April 9, 2018 – June 10, 2019 Ongoing
Number of transplants 17 times
Change from first transplant to end of transplant:.
【1st transplantation questionnaire】 Post-transplant posterior tremor has stopped. Glutathione infusion, hydrogen infusion, and inhalation will be temporarily discontinued during future transplantation.
【2nd transplantation questionnaire】 Tremor subsided somewhat and sleep improved.
【3rd transplantation questionnaire】 Tremor improved further. Bowel movements are the result of the use of Chinese herbal medicine.
【4th transplantation questionnaire】 Improvement effect of tremor is maintained. Relies on Chinese herbal medicine for bowel movements.
【5th transplantation questionnaire】 Improvement effect of tremor is maintained. Relies on Chinese herbal medicine for bowel movements.
【6th transplantation questionnaire】 Tremor remains in the right leg. Bowel movements do not improve much.
【7th transplantation questionnaire】 Improvement effect of tremor was maintained.
【8th transplantation questionnaire】 Tremor remains.
【9th transplantation questionnaire】 Tremor in arms and legs remained.
【10th transplantation questionnaire】 Tremor in arms and legs remained and became stronger when strained. She had a fall when walking on the stairs.
【11th transplantation questionnaire】 Tremor remains.
【12th transplantation questionnaire】 Tremor in arms and legs remained and became stronger during tension.
【14th transplantation questionnaire】 Patient has a little residual tremor and is constipated.
【15th transplantation questionnaire】 She still has tremor in her arms and legs, and constipation persists.
【16th transplantation questionnaire】 Tremor in the hands remains and becomes stronger with tension and fatigue.
【17th transplantation questionnaire】 She had residual tremor in her hands and constipation.
Changes after completion of transplant:.
Tremors in arms and legs, constipation, and little improvement in physical condition have not been observed. (Progress)

Evaluation and Discussion

Transplant Evaluation:. No change
Pre- and post-transplant flora balance test changes:. [Before transplant] March 2018. The clostridium is unbalanced, low diversity, and typically stressful. It is speculated that there is some suppressed stimulation of the brain, which may be a counterbalance. I believe that an improvement in the balance will improve symptoms.
[During transplantation] June 2018. The balance has improved along with the diversification of the Clostridium genus, which was a problem prior to the transplant, and I believe the balance has acquired mental calm. However, the growth of fungi and viruses may be causing a fungal shift phenomenon, pushing other fungi away on the balance graph. We recommend prescribing antifungal medications or testing for fungi and viruses.
Blood test changes:. ［After transplantation] None
POMS2 SCORE CHANGE:. ［After transplantation] None
＜Intestinal flora balance before and after transplantation＞
His/her experience (from the questionnaire):.
None at present
Adverse events: No
Nothing
Transplant General Comments and Discussion:.
At the time of the 17th transplant, the tremor of Parkinson’s disease persists, but has somewhat improved and progression has stopped compared to the initial visit. Constipation is similar and he is taking laxatives regularly. Glutathione infusion, hydrogen infusion, and oral Rejuzyn are continued.
… and upwards
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