Intestinal flora transplantation and case studies

Fecal microflora transplant case report] Ulcerative colitis, 50s male

Case presentation: Male in his 50s, ulcerative colitis

summary

Subjective symptoms (diarrhea, frequency of bowel movements, high gas, etc.) are indicators. After the first transplant, gas retention improved and stools became slightly firmer. After the second transplant, abdominal and defecation symptoms continued to improve. In addition, the chronic nasal obstruction also improved.

Basic Information

Patients :50s Male
Attending physician :Futakotamagawa Medical Clinic
Medical institution in charge of transplantation :Futakotamagawa Medical Clinic

Information at the time of initial medical examination

Disease name :Ulcerative colitis, irritable bowel syndrome, anal failure
Time of onset :Since about October 1990
Transplant Purpose: ToDiarrhea, gas
Chief complaint :Abdominal pain and other diarrhea gas is common.
Medications being taken :Iribo, mesalazine, coronel, trans-colon, gascon, trimeptin maleate
Medical history :Diabetes with high blood pressure
Background, family history, lifestyle, supplement use, etc :

Transplant Information

Transplantation period: fromMarch 5, 2020 – March 19, 2020
Number of transplants :3 times
Change from first transplant to end of transplant :
3 transplants conducted

【1st transplantation questionnaire】
Gas is the most common concern. Colonic or soluble stools occur in response to mental status. Feels restricted in activities and affected in socializing. Has anal insufficiency.

【2nd transplantation questionnaire】
Gas retention feeling is a little better. Defecation has improved, but it is still hard. Still too scared to take the train.

【3rd transplantation questionnaire】
Gas accumulation improved. Stools are good. No more putrid smell.

【Questionnaire at the examination】
His stools are in much better shape. He hopes the gas will settle down a little more.
Changes after completion of transplant :
Subjective symptoms (diarrhea, frequency of bowel movements, gas, etc.) are indicators. After the first transplant, gas retention improved and stools became slightly firmer; after the second transplant, abdominal and defecation symptoms continued to improve. In addition, the patient’s chronic nasal obstruction also improved. Although the chronic symptoms had not improved despite continued medical therapy at another hospital, the transplantation resulted in the formation of stools and no more leakage of soft stools due to anorectal insufficiency. Furthermore, the symptoms of abdominal bloating associated with excessive gas retention also tended to lessen, so a three-transplant course was also effective. Further improvement would be expected with additional transplants.

evaluation

Transplant Evaluation :Clear improvement of symptoms

< Intestinal flora balance 1st data >

< Intestinal flora balance 2nd data >

His/her experience (from the questionnaire) :
During the transplant period, I felt the effects a little. I am not sure if the effect will continue, but I am trying to review my diet. I am very grateful for the stools.
Adverse events: No
Nothing
Transplant General Comments and Discussion :
Under observation and under consideration for additional transplantation

… and upwards


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