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Intestinal flora transplantation and case studies

Dysautonomia and Adrenal Fatigue Syndrome, Female in her 40s -Fecal Microflora Transplantation Case Report

Case presentation: Female in her 40s,  depression tendency

summary

Since meniscus knee surgery in September, I have been depressed and feel better in the morning but worse in the afternoon and evening. She feels better at night. Her bowel movements are sluggish with a feeling of residual bowel movements. She has little appetite, especially during menstruation and ovulation. Sleep is shallow, palms are sweaty, and sympathetic nerves are tense.

Basic Information

Patients : 40s Female
Attending physician : Haruna Clinic
Medical institution in charge of transplantation : Haruna Clinic

Information at the time of initial medical examination

Disease name : depressive tendency
Time of onset : October 2018
Transplant Purpose: To Depressive symptoms (mood swings)
Fatigue
Sleep disturbances
Loss of appetite
Chief complaint : Depression-induced mood swings, overstress, fatigue, loss of appetite
Medications being taken : Nothing
Medical history : September 2018 left knee meniscus surgery
Background, family history, lifestyle, supplement use, etc : Lactobacillus supplement, Ecryol

Transplant Information

Transplantation period: from July 9, 2019 – July 30, 2019
Number of transplants : 3 times
Change from first transplant to end of transplant :

After the first session, I started to sleep more deeply and feel a little hungrier. My poor condition has also improved a little. 2nd and 3rd time, I started to have a good appetite and sleep well.

【1st transplantation questionnaire】
She feels well in the morning, but becomes fatigued in the afternoon and evening, and then gets better in the evening.
She has bowel movements every day, but there is a lingering sensation of a stool, and she feels her stomach is tight.
【2nd transplantation questionnaire】
Emotionally, there is no significant change.
No bacterial fluid after transplant and normal stools the next day.
【3rd transplantation questionnaire】
Bowel movements are getting better.
I feel a little better emotionally.
Sleep is getting better.
【Questionnaire 3 months after transplantation】
The change in her mood has lessened since the transplantation, and her appetite has increased.
Sleep is good with a sense of sound sleep.
She is considering what to do about her menstruation and ovulation problems.
Changes after completion of transplant :
Her appetite has improved and her energy is increasing, though not completely.
She is considering what to do about her menstrual and ovulation problems.

Evaluation and Discussion

Transplant Evaluation : Moderate improvement of symptoms
Pre- and post-transplant flora balance test changes : There is a decrease in brautia and the inflammatory immune overload is improving. Also, diversity is emerging.
However, the percentage of Clostridium 9 is increasing, and it may be important to observe a little more regarding the mental aspect and stability of the intestinal flora.
Blood test changes : No particular change.
POMS2 SCORE CHANGE : TMD HAS NOT CHANGED MUCH, FROM 50 TO 52, BUT TA HAS IMPROVED FROM 20 TO 15, WHICH SEEMS TO HAVE REDUCED ANXIETY AND OTHER SYMPTOMS.

＜Intestinal flora balance before transplant data＞

＜Intestinal flora balance Post-transplant data＞

His/her experience (from the questionnaire) :
Appetite and sleep are better and a little more vibrant.
Adverse events: No
Nothing
Transplant General Comments and Discussion :
Since the end of the first transplant, his appetite and sleep have improved, and there have been no other changes, so the transplant seems to have had an effect.

… and upwards

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