Irritable bowel syndrome, male in his 80’s – Case report of fecal microbiota transplantation
Irritable bowel syndrome, male in his 80’s – Case report of fecal microbiota transplantation
summary
Constant gas in the abdomen, pressure and dull pain throughout the day. Farting and burping frequently, regardless of whether it is before or after meals. Constipation most days, with 5~6 small bowel movements in a day. Abdominal pain always occurs after each bowel movement. The pain subsides after about an hour, but the same condition repeats itself every day. Diarrhea is rare. Transplantation is started with the above symptoms.
After the first transplant, the frequency of bowel movements decreased from 5-6 times/day to 3 times/day, and after the second transplant, it decreased to 2 times/day, but abdominal distention and abdominal pain after bowel movements persisted. After 5 and 6 transplants, she had 6 stools, and her abdominal distention and abdominal pain did not improve.
Basic Information
| Patients : | Male in his 80s |
| Attending physician : | Medical Corporation Keimeikai Kimura Hospital |
| Medical institution in charge of transplantation | Medical Corporation Keimeikai Kimura Hospital |
Information at the time of initial medical examination
| Disease name : | irritable bowel syndrome |
| At onset : | March 2019 |
| Transplant Purpose: To | Improvement of disease, constipation and gas accumulation |
| Chief complaint : | Constant gas in the abdomen, pressure and dull pain throughout the day. Farting and burping frequently, regardless of whether it is before or after meals. Constipation, with 5 to 6 small bowel movements in a day. Abdominal pain always occurs after each bowel movement. The pain subsides after about an hour, but the same condition repeats itself every day. Diarrhea is rare. In the morning, when she goes to bed, her bowels rumbles and she feels a dull pain. He has a good appetite but has recently lost weight. The abdominal pain continues throughout the day, making it hard on the body. Colonoscopy, gastroscopy, and pet examination are performed, but no abnormalities are found. |
| Medical history : | Intervertebral disc herniation, benign prostatic hyperplasia |
| Background, family history, lifestyle, supplement use, etc : | Pain medications, intestinal preparations |
Transplant Information
| Transplantation period: from | 7/21/2021~9/1/2021 |
| Number of transplants : | 6 transplants |
| Change from first transplant to end of transplant : |
| Symptoms improved after the first and second transplants, but no improvement was observed after the subsequent transplants. Symptoms were the same as before transplantation. 【1st transplantation questionnaire】 (From the patient) He defecates 5-6 times a day. Pain during defecation. Abdomen: no abdominal tenderness 【2nd transplantation questionnaire】 (From the patient) The frequency of bowel movements decreased from about 6 times to about 3 times. Abdominal pain during defecation remains the same. Persistent abdominal distention. Abdomen: mild tenderness in lower abdomen Bowel sounds: slightly increased. 【3rd transplantation questionnaire】 (From patient) Soft stools and frequency of bowel movements has decreased to about twice a day. Abdominal fullness and abdominal pain after defecation persist. Abdomen: abdominal distention Bowel sounds: slightly elevated 【4th transplantation questionnaire】 (From patient) Soft stools and frequency of bowel movements has increased. Abdominal pain after defecation. Abdomen: tenderness in the lower part of the navel. Bowel sounds: increased. 【5th transplantation questionnaire】 (From patient) Defecation about 6 times a day is the same, not diarrhea but soft stool. Abdominal pain during defecation is the same as after the last transplant. Abdomen: bloating 【6th transplantation questionnaire】 (From the patient) Symptoms are the same as after the last transplant. 6 defecations per day, not diarrhea, but soft stools are still present. She has abdominal pain during defecation and continues to have abdominal distention as well. Abdomen: mild tenderness over lower abdomen Bowel sounds: slightly elevated |
Intestinal flora balance Comparative data
Evaluation and Discussion
| Transplant Evaluation : | No change |
| Adverse events: No | Nothing |
| Transplant Evaluation : |
| The first and second transplants showed improvement, but no improvement was observed in subsequent transplants, and the symptoms were the same as before transplantation. |
… and upwards
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The number of actual fecal microbiota transplants by case in our study group is as follows Case reports by disease You can view case reports by disease from the links below: [Ulcerative Colitis]https://fmt-japan.org/research-activities/fmt-cases-index?tag=uc [Irritable Bowel Syndrome]https://fmt-japan.org/research-activities/fmt-cases-index?tag=ibs [Atopic Allergies]https://fmt-japan.org/research-activities/fmt-cases-index?tag=allergy [Constipation]https://fmt-japan.org/research-activities/fmt-cases-index?tag=constipation [ASD (Autism Spectrum Disorder)]https://fmt-japan.org/research-activities/fmt-cases-index?tag=asd [Other Diseases]https://fmt-japan.org/research-activities/fmt-cases-index?tag=others
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