Intestinal flora transplantation and case studies

Atopy and allergy in a woman in her 40s – Case report of fecal microflora transplantation

Case Introduction 40s female, atopic dermatitis/allergy

summary

Basic Information

Patients : Woman in her 40s
Attending physician : Luke’s Ashiya Clinic
Medical institution in charge of transplantation : Luke’s Ashiya Clinic

Information at the time of initial medical examination

Disease name : Atopic Allergies
At onset : unknown
Transplant Purpose: To
Tiredness
Allergies (food, pollen, chemicals, etc.)
Skin problems (including atopy)
sleep disorder
Chief complaint : INITIAL CONSULTATION AT TANAKA CLINIC NUTRITIONAL THERAPY INCLUDING DIET, SUPPLEMENTS, ETC., AND THE IMPORTANCE OF INTESTINAL ENVIRONMENT AFTER BLOOD TEST ON NUTRITIONAL THERAPY AT OTHER CLINIC, RETURN VISIT TO EXPLAIN ABOUT INTESTINAL FLORA TRANSPLANTATION AND SUBSEQUENT NUTRITIONAL MANAGEMENT. IMMUNE FUNCTION (FACS) WAS PERFORMED TO ESTIMATE THE INTESTINAL ENVIRONMENT. AT THE TIME OF VISIT TO LUKE’S ASHIYA CLINIC, THE PATIENT HAD COMPLAINTS OF EDEMA, COLDNESS, PAIN, FATIGUE, AND DIARRHEA IN THE LOWER EXTREMITIES, BUT NO CLEAR DIAGNOSIS WAS MADE.
Medications being taken : Nothing
Medical history :
Background, family history, lifestyle, supplement use, etc : Tobacco over 25 years

Transplant Information

Transplantation period: from November 15, 2019 – November 29, 2019
Number of transplants : 3 times
Change from first transplant to end of transplant :
【1st transplantation questionnaire】
Recently, the soles of my feet have been hurting. I have pain all over my body and would like to get some relief from that. My hands and face are hot. I couldn’t get up this morning.
He is hungry because he came to the hospital fasting for a blood draw. He has a peripheral cold sensation in his lower extremities.

【2nd transplantation questionnaire】 After the first transplant, the burning in my arms, legs, and neck has lessened. Bowel movements also improved a little.
【3rd transplantation questionnaire】 Decreased frequency of leg pain and queasiness, which used to be symptomatic in the evening. She had always had a bloating feeling in her stomach in the evening, but it has also disappeared. She seems to have seen a reduction in her physical sensations and symptoms, and speaks cheerfully.
Changes after completion of transplant :
Bowel movements, fatigue, coldness, and swelling are improving.
Mood changes. (It’s getting better.)

Evaluation and Discussion

Transplant Evaluation : Clear improvement of symptoms
Pre- and post-transplant flora balance test changes : [PRIOR TO TRANSPLANTATION] SEPTEMBER 2019. THERE ARE NO PARTICULAR PROBLEMS WITH OVERALL GUT FLORA AND C. CLUSTER DIVERSITY. HOWEVER, THERE IS A SLIGHT BALANCE PROBLEM. THE PERCENTAGE OF LACTOBACILLUS, BACTEROIDES, AND PREVOTELLA IS LOW AND THE PERCENTAGE OF C. CLUSTER IX IS SLIGHTLY HIGH. THERE IS AN IMPRESSION THAT IMPROVEMENT CAN BE EXPECTED WITH THE LACK OF EXTREME BALANCE VARIATION, MEDICATION INCLUDING SUPPLEMENTS FOR THE QUESTIONNAIRE, AND A REVIEW OF DIETARY HABITS.
[During transplantation] None
[After transplantation] None
Blood test changes : [After transplantation] None
POMS2 SCORE CHANGE : Nothing
<Intestinal flora balance before transplant data> <Intestinal flora balance Post-transplant data>
His/her experience (from the questionnaire) :
No reply
Adverse events: No
Nothing
Transplant General Comments and Discussion :
ALTHOUGH NOT WELL REFLECTED IN THE POMS, SUBJECTIVE SYMPTOMS ARE CONSIDERED TO BE IMPROVING.

Related Videos

DATE: 4/5/2019 FUTURE PROSPECTS FOR NEXT GENERATION INTESTINAL FLORA TRANSPLANTATION 131ST MVC REGULAR MEETING PRESENTER: DR. MASAHIKO JOHYA, LUKE’S ASHIYA CLINIC
… and upwards
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Fecal microbiota transplantation results *As of September , 2025

The number of actual fecal microbiota transplants by case in our study group is as follows Case reports by disease You can view case reports by disease from the links below: [Ulcerative Colitis]https://fmt-japan.org/research-activities/fmt-cases-index?tag=uc [Irritable Bowel Syndrome]https://fmt-japan.org/research-activities/fmt-cases-index?tag=ibs [Atopic Allergies]https://fmt-japan.org/research-activities/fmt-cases-index?tag=allergy [Constipation]https://fmt-japan.org/research-activities/fmt-cases-index?tag=constipation [ASD (Autism Spectrum Disorder)]https://fmt-japan.org/research-activities/fmt-cases-index?tag=asd [Other Diseases]https://fmt-japan.org/research-activities/fmt-cases-index?tag=others

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